Research on harmful chemicals

The interdisciplinary and integrated research approach in EDC-MixRisk focuses on the effects of mixtures of endocrine disrupting chemicals (EDCs) on children.

Three health domains are defined: growth and metabolism, neurodevelopment, and sexual development. The researchers involved will develop risk assessment of EDC mixtures through improved understanding of health effects in these domains and underlying mechanisms.

Epidemiology, experimental research and risk assessment

EDC-MixRisk is divided into three scientific modules: 1: Epidemiology, 2: Experimental research and 3: Risk assessment and societal impact:

1: Epidemiological studies will be used to identify EDC mixtures correlated to adverse health outcomes on growth and metabolism, neurodevelopment, and sexual development. Two large European epidemiological pregnancy cohort studies (SELMA and The LIFE Child Study), including over 1000 mother-child pairs followed from early pregnancy up in school age, will be used for identifying critical EDC mixtures that are related to adverse health outcomes in these domains.

2: Experimental investigations in animal and cell models will uncover molecular mechanisms underlying effects seen in the epidemiological studies, focusing on finding molecular initiation events and understanding adverse outcome pathways.

3: EDC-MixRisk will develop a transparent, consistent and systematic framework in risk assessment for integrating epidemiological and experimental research to facilitate risk assessment for EDCs and mixtures.

This interdisciplinary approach, integrating epidemiologic and experimental evidence, will aim at better risk assessment and management of EDCs and their mixtures.

Publications:

Bornehag, C. G., Kitraki. E., Panagiotidou. E., Stamatakis. A., Ruden. C., Shu. H., Lindh. C., Ruegg. J., Gennings. C. A novel approach to chemical mixture risk assessment – Linking data from population based epidemiology and experimental animal tests. Risk analysis.
Accepted for publication

Gennings, C., Shu, H., Rudén, C., Öberg, M., Lindh, C., Kiviranta, H., Bornehag, C-G. (2018):
Incorporating regulatory guideline values in analysis of epidemiology data
Environment International. Volume 120, Pages 535-543.
doi: 10.1016/j.envint.2018.08.039
Read the abstract

Mughal B., Fini J-B., Demeneix B. (2018):
Thyroid-disrupting chemicals and brain development: an update.
Endocrine Connections. 2018;7(4):R160-R186. doi: 10.1530/EC-18-0029.
Read the paper

Alavian-Ghavanini, A., Rüegg, J. (2018):
Understanding Epigenetic Effects of Endocrine Disrupting Chemicals: From Mechanisms to Novel Test Methods.
Basic & Clinical Pharmacology & Toxicology. Volume 122, Issue 1, pages 38-45.
doi: 10.1111/bcpt.12878
Read the paper

Jacobs, M., Marczylo, E., Guerrero-Bosagna, C., Rüegg J. (2017):
Marked for Life: Epigenetic Effects of Endocrine Disrupting Chemicals.
Annual Review of Environment and Resources. Volume 42, pages 105-160.
doi: 10.1146/annurev-environ-102016-061111
Read the paper

Savchuk, I., Morvan, M.L., Antignac, J.P., Gemzell-Danielsson, K., Le Bizec, B., Söder O., Svechnikov K. (2017):
Androgenic potential of human fetal adrenals at the end of the first trimester
Endocrine Connections. Volume 6, no. 6, pages 348-359. doi: 10.1530/EC-17-0085
Read the paper

Fini, J-B., Mughal, B., Le Mével, S., Leemans, M., Lettmann, M., Spirhanzlova, P., Affaticati, P., Jenett, A., Demeneix, B. (2017):
Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos.
Scientific Reports. No. 7: 43786. doi: 10.1038/srep43786
Read the paper

Hoffmann, M., Gebauer, S., Nüchter, M., Baber, R., Ried, J., von Bergen, M., Kiess W. (2017):
Endokrine Modulatoren. [Endocrine disruptors : Evidence from epidemiological studies necessitates a critical review of model systems]
Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz. Jun; 60(6): 640-648. doi: 10.1007/s00103-017-2551-8
Read the abstract in English

Kitraki, E., Nalvarte I., Alavian-Ghavanini A., Rüegg J. (2016):
Effects of pre- and post-natal exposure to bisphenol A on the stress system.
Endocrine Disruptors. Volume 4, Issue 1. doi: 10.1080/23273747.2016.1184775
Read the paper

Solecki R., Kortenkamp, A., Bergman, Å., Chahoud, I., Degen G., Dietrich, D., Greim, H., Håkansson, H., Hass, U., Husoy, T., Jacobs, M., Jobling, S., Mantovani, A., Marx-Stoelting, P., Piersma, A., Ritz, V., Slama, R., Stahlmann, R., van den Berg, M., Zoeller, T., Boobis A. (2016):
Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement.
Archives of Toxicology. Volume 91, Issue 2, pages 1001–1006.
doi: 10.1007/s00204-016-1866-9
Read the paper

Lind, L., Lind, M., Lejonklou, M., Dunder, L., Bergman, Å., Guerrero-Bosagna, C., Lampa, E., Kyu Lee, H., Legler, J., Nadal, A., Kim Pak, Y., Phipps, R., Vandenberg, L., Zalko, D., Ågerstrand, M., Öberg, M., Blumberg, B., Heindel, J., Birnbaum L. (2016):
Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic.
Environmental Health Perspectives. 124:A81–A83. doi: 10.1289/ehp.1511115
Read the paper

EDC-MixRisk – Safe chemicals for future generations