The interdisciplinary and integrated research approach in EDC-MixRisk focuses on the effects of mixtures of endocrine disrupting chemicals (EDCs) on children.

Three health domains are defined: growth and metabolism, neurodevelopment, and sexual development. The researchers involved will develop risk assessment of EDC mixtures through improved understanding of health effects in these domains and underlying mechanisms.

Epidemiology, experimental research and risk assessment

EDC-MixRisk is divided into three scientific modules: 1: Epidemiology, 2: Experimental research and 3: Risk assessment and societal impact:

Doctor showing statistic on a tablet. Photo: NEC Corporation of America with CC.

1: Epidemiological studies will be used to identify EDC mixtures correlated to adverse health outcomes on growth and metabolism, neurodevelopment, and sexual development. Two large European epidemiological pregnancy cohort studies (SELMA and The LIFE Child Study), including over 1000 mother-child pairs followed from early pregnancy up in school age, will be used for identifying critical EDC mixtures that are related to adverse health outcomes in these domains.

2: Experimental investigations in animal and cell models will uncover molecular mechanisms underlying effects seen in the epidemiological studies, focusing on finding molecular initiation events and understanding adverse outcome pathways.

3: EDC-MixRisk will develop a transparent, consistent and systematic framework in risk assessment for integrating epidemiological and experimental research to facilitate risk assessment for EDCs and mixtures.

This interdisciplinary approach, integrating epidemiologic and experimental evidence, will aim at better risk assessment and management of EDCs and their mixtures.

Publications:

Gennings, C., Shu, H., Rudén, C., Öberg, M., Lindh, C., Kiviranta, H., Bornehag, C-G. (2018):
Incorporating regulatory guideline values in analysis of epidemiology data
Environment International. Volume 120, Pages 535-543.
doi: 10.1016/j.envint.2018.08.039
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Mughal B., Fini J-B., Demeneix B. (2018):
Thyroid-disrupting chemicals and brain development: an update.
Endocrine Connections. 2018;7(4):R160-R186. doi: 10.1530/EC-18-0029.
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Alavian-Ghavanini, A., Rüegg, J. (2018):
Understanding Epigenetic Effects of Endocrine Disrupting Chemicals: From Mechanisms to Novel Test Methods.
Basic & Clinical Pharmacology & Toxicology. Volume 122, Issue 1, pages 38-45.
doi: 10.1111/bcpt.12878
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Jacobs, M., Marczylo, E., Guerrero-Bosagna, C., Rüegg J. (2017):
Marked for Life: Epigenetic Effects of Endocrine Disrupting Chemicals.
Annual Review of Environment and Resources. Volume 42, pages 105-160.
doi: 10.1146/annurev-environ-102016-061111
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Savchuk, I., Morvan, M.L., Antignac, J.P.,  Gemzell-Danielsson, K., Le Bizec, B., Söder O., Svechnikov K. (2017):
Androgenic potential of human fetal adrenals at the end of the first trimester
Endocrine Connections. Volume 6, no. 6, pages 348-359. doi: 10.1530/EC-17-0085
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Fini, J-B., Mughal, B., Le Mével, S., Leemans, M., Lettmann, M., Spirhanzlova, P., Affaticati, P., Jenett, A., Demeneix, B. (2017):
Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos.
Scientific Reports. No. 7: 43786. doi: 10.1038/srep43786
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Hoffmann, M., Gebauer, S., Nüchter, M., Baber, R., Ried, J., von Bergen, M., Kiess W. (2017):
Endokrine Modulatoren. [Endocrine disruptors : Evidence from epidemiological studies necessitates a critical review of model systems]
Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz. Jun; 60(6): 640-648. doi: 10.1007/s00103-017-2551-8
Read the abstract in English

Kitraki, E., Nalvarte I., Alavian-Ghavanini A., Rüegg J. (2016):
Effects of pre- and post-natal exposure to bisphenol A on the stress system.
Endocrine Disruptors. Volume 4, Issue 1. doi: 10.1080/23273747.2016.1184775
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Solecki R., Kortenkamp, A., Bergman, Å., Chahoud, I., Degen G., Dietrich, D., Greim, H., Håkansson, H., Hass, U., Husoy, T., Jacobs, M., Jobling, S., Mantovani, A., Marx-Stoelting, P.,  Piersma, A., Ritz, V., Slama, R., Stahlmann, R., van den Berg, M., Zoeller, T., Boobis A. (2016):
Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement.
Archives of Toxicology. Volume 91, Issue 2, pages 1001–1006.
doi: 10.1007/s00204-016-1866-9
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Lind, L., Lind, M., Lejonklou, M., Dunder, L., Bergman, Å., Guerrero-Bosagna, C., Lampa, E., Kyu Lee, H., Legler, J., Nadal, A., Kim Pak, Y., Phipps, R., Vandenberg, L., Zalko, D.,  Ågerstrand, M., Öberg, M., Blumberg, B., Heindel, J., Birnbaum L. (2016):
Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic.
Environmental Health Perspectives. 124:A81–A83. doi: 10.1289/ehp.1511115
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Read more about our research in your language:

English: EDC-MixRisk_English

Finnish: EDC-MixRisk_Suomi

French:EDC-MixRisk_Français

German: EDC-MixRisk_Deutsch

Greek: EDC-MixRisk_στα ελληνικα

Italian:EDC-MixRisk_Italiano

Swedish: EDC-MixRisk_Svenska