The interdisciplinary and integrated research approach in EDC-MixRisk focuses on the effects of mixtures of endocrine disrupting chemicals (EDCs) on children.

Three health domains are defined: growth and metabolism, neurodevelopment, and sexual development. The researchers involved will develop risk assessment of EDC mixtures through improved understanding of health effects in these domains and underlying mechanisms.

Epidemiology, experimental research and risk assessment

EDC-MixRisk is divided into three scientific modules: 1: Epidemiology, 2: Experimental research and 3: Risk assessment and societal impact:

Doctor showing statistic on a tablet. Photo: NEC Corporation of America with CC.

1: Epidemiological studies will be used to identify EDC mixtures correlated to adverse health outcomes on growth and metabolism, neurodevelopment, and sexual development. Two large European epidemiological pregnancy cohort studies (SELMA and The LIFE Child Study), including over 1000 mother-child pairs followed from early pregnancy up in school age, will be used for identifying critical EDC mixtures that are related to adverse health outcomes in these domains.

2: Experimental investigations in animal and cell models will uncover molecular mechanisms underlying effects seen in the epidemiological studies, focusing on finding molecular initiation events and understanding adverse outcome pathways.

3: EDC-MixRisk will develop an approach for evaluating, integrating and synthesizing complex datasets for EDCs and mixtures.

This interdisciplinary approach, integrating epidemiologic and experimental evidence, will facilitate assessment of risk and societal impact aiming at better risk management for EDCs and their mixtures.

Publications:

Ali Alavian-Ghavanini, Joëlle Rüegg (2018):
Understanding Epigenetic Effects of Endocrine Disrupting Chemicals: From Mechanisms to Novel Test Methods.
Basic & Clinical Pharmacology & Toxicology. Volume 122, Issue 1, pages 38-45.
DOI: 10.1111/bcpt.12878
Read the paper

Miriam N. Jacobs, Emma L. Marczylo, Carlos Guerrero-Bosagna, Joëlle Rüegg (2017):
Marked for Life: Epigenetic Effects of Endocrine Disrupting Chemicals.
Annual Review of Environment and Resources. Volume 42, pages 105-160.
DOI: 10.1146/annurev-environ-102016-061111
Read the paper

I Savchuk, M L Morvan, J P Antignac, K Gemzell-Danielsson, B Le Bizec, O Söder, K Svechnikov (2017):
Androgenic potential of human fetal adrenals at the end of the first trimester
Endocrine Connections. Volume 6, no. 6, pages 348-359. DOI: 10.1530/EC-17-0085
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Jean-Baptiste Fini, Bilal B. Mughal, Sébastien Le Mével, Michelle Leemans, Mélodie Lettmann, Petra Spirhanzlova, Pierre Affaticati, Arnim Jenett, Barbara A. Demeneix (2017):
Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos.
Scientific Reports. No. 7: 43786. DOI: 10.1038/srep43786
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Hoffmann, S. Gebauer, M. Nüchter, R. Baber, J. Ried, M. von Bergen, W. Kiess (2017):
Endokrine Modulatoren. [Endocrine disruptors : Evidence from epidemiological studies necessitates a critical review of model systems]
Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz. Jun; 60(6): 640-648. DOI: 10.1007/s00103-017-2551-8
Read the abstract in English

Kitraki, I. Nalvarte, A. Alavian-Ghavanini, J. Rüegg (2016):
Effects of pre- and post-natal exposure to bisphenol A on the stress system.
Endocrine Disruptors. Volume 4, Issue 1. DOI: 10.1080/23273747.2016.1184775
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Roland Solecki, Andreas Kortenkamp, Åke Bergman, Ibrahim Chahoud, Gisela H. Degen, Daniel Dietrich, Helmut Greim, Helen Håkansson, Ulla Hass, Trine Husoy, Miriam Jacobs, Susan Jobling, Alberto Mantovani, Philip Marx-Stoelting, Aldert Piersma, Vera Ritz, Remy Slama, Ralf Stahlmann, Martin van den Berg, R. Thomas Zoeller, Alan R. Boobis (2016):
Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement.
Archives of Toxicology. Volume 91, Issue 2, pages 1001–1006.
DOI: 10.1007/s00204-016-1866-9
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Lars Lind, P. Monica Lind, Margareta H. Lejonklou, Linda Dunder, Åke Bergman, Carlos Guerrero-Bosagna, Erik Lampa, Hong Kyu Lee, Juliette Legler, Angel Nadal, Youngmi Kim Pak, Richard P. Phipps, Laura N. Vandenberg, Daniel Zalko, Marlene Ågerstrand, Mattias Öberg, Bruce Blumberg, Jerrold J. Heindel, Linda S. Birnbaum (2016):
Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic.
Environmental Health Perspectives. 124:A81–A83. DOI: 10.1289/ehp.1511115
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Read more about our research in your language:

English: EDC-MixRisk_English

Finnish: EDC-MixRisk_Suomi

French:EDC-MixRisk_Français

German: EDC-MixRisk_Deutsch

Greek: EDC-MixRisk_στα ελληνικα

Italian:EDC-MixRisk_Italiano

Swedish: EDC-MixRisk_Svenska